Glossary of Terms and Abbreviations
Information on Key Clinical Trial Terms
The following is a list of abbreviations.
For a complete list of clinical trial terms, please click here.
- AAUCMB
- Average Area Under the Curve Minus Baseline
- ABS
- Abacavir
- ACR 20
- American College of Rheumatology 20% responder rate
- ADE
- AIDS- Defining Event
- ADR
- Adverse Drug Reaction
- AE
- Adverse Event
- Ae
- Amount excreted in urine
- Aet
- Cumulative urinary excretion from administration until time t
- AIDS
- Acquired Immunodeficiency Deficiency Syndrome
- ALT
- Al anine aminotransferse
- ANC
- Absolute Neutrophil Count
- ANCOVA
- Analysis of covariance
- ANOVA
- Analysis of variances
- anti-HAT
- Humanized Anti-Tac
- anti-TNF
- Anti-Tumor Necrosis Factor
- anti-TNFα
- Anti-Tumor Necrosis Factor-alpha
- APV
- Amprenavir
- ARA
- American Rheumatism Association
- ARV
- Antiretroviral
- AUC
- Area Under the Curve
- AUC0-∞
- Area Under the Curve time 0-time infinity
- AUCinf
- Area under the Curve time infinity
- AUCMB
- Area under the Curve minus baseline
- Bid
- bis in die (twice daily)
- BL
- Baseline
- BLQ
- Below Limit of Quantification
- CA
- Competent Authority
- CCRC
- Certified Clinical Research Coordinator
- CI
- Confidence Interval
- CL/F
- Apparent clearance
- CLdtot
- Total distribution clearance
- CLiv
- Clearance after iv administration
- CLpo
- Oral clearance
- CLR
- Renal clearance
- Cmax
- Maximum plasma concentration
- Cmin
- Minimum plasma concentration
- CMV
- Cytomegalovirus retinitis
- CMVR
- Cytomegalovirus retinitis
- CRA
- Clinical Research Associate
- CRC
- Clinical Research Coordinator
- CrCl
- Creatinine Clearance
- CRF
- Case Report Form
- CRO
- Contract Research Organization
- CRP
- C-reactive protein
- Css
- Plasma concentration at steady state
- Cthrough
- Through plasma concentration
- CTx
- C-teleopeptide
- d
- day
- D+
- Cytomegalovirus-seropositive donor
- DAR
- Drug or Device Accountability Records
- dL
- deciliter
- DMARD
- Disease-Modifying Anti-Rheumatic Drug
- DT
- Diphtheria/Tetanus
- ECG/EKG
- Electrocardiogram
- EFV
- Efavirenz
- EMEA
- see European Medicines Agency
- EORTC
- European Organization for Research and Treatment of Cancer
- ESR
- Erythrocyte Sedimentation Rate
- F
- Bioavailability
- FDA
- Food and Drug Administration
- FSGS
- Focal Segmental Glomerulosclerosis
- g
- gram
- GC-MS
- Gas Chromatograph Mass Spectrometer
- GCP
- Good Clinical Practice
- GGT
- Gamma-Glutamyl Transferase
- HAART
- Highly Active Antiretroviral Therapy
- HAQ
- Health Assessment Questionaire
- HIV
- Human Immunodeficiency Virus
- hr
- hour
- IEC
- Independent Ethics Committee
- IND
- Investigational New Drug Application
- IRB
- Institutional Review Board
- ISR
- Injection Site Reaction
- ITT
- Intention To Treat
- Iv
- Intravenous
- Kel
- Elimination constant
- kg
- kilogram
- LC/MS/MS methods
- Liquid Chromatography mass spectrometery
- LOCF
- Last Observation Carried Forward
- Longitudinal Study
- A study conducted over a long period of time.
- LSM
- Least Squares Mean
- m
- meter
- mcg
- microgram
- mg
- milligram
- MITT
- Modified Intention To Treat
- mL
- millilitre
- mm
- millimetre
- mmol
- millimole
- MOS
- Medical Outcomes Study
- MPA
- Mycophenolic Acid
- MPAG
- Mycophenolic Acid Glucuronide
- MTX
- Methotrexate
- NAG
- N-acetyl-β-D-glucosaminidase
- NDA
- New Drug Application
- ng
- nanogram
- OB
- Optimized Background
- OHRP
- Office for Human Research Protection
- OTC
- Over-the-Counter
- PD
- Pharmacodynamics
- PI
- Protease Inhibitor
- PK
- Pharmacokinetic
- PNBC
- Periods with New Bone Complications
- Po
- per os (oral)
- Pts-yrs
- Patient-years
- PWFU
- Patients who Withdrew From study prematurely
- q12h
- every 12 hours
- QLQ-C30
- Quality of Life Questionnaire-core 30
- QOL
- Quality Of Life
- qow
- every other week
- R-
- Cytomegalovirus-seronegative
- RA
- Rheumatoid arthritis
- RNA
- Ribonucleic Acid
- RT
- Restricted Treated
- RTV
- Ritonavir
- SAE
- see Serious Adverse Event
- sc
- subcutaneous
- SD
- Standard Deviation
- SEM
- Standard Error of the Mean
- SF-36
- Short-Form 36
- SMPR
- Skeletal Morbidity Period Rate
- SOP
- Standard Operating Procedure
- SOT
- Solid Organ Transplant
- t1/2p
- Bioloogical half-life of parent compound
- t1/2u
- Urinary half-life
- TBW
- Total Body Weight
- tid
- thrice daily
- Tmax
- Time to maximum plasma concentration
- TT
- Tetanus Toxoid
- V1
- Central (vascular) compartment
- V2
- Peripheral (extra-vascular) compartment
- Vss
- volume of distribution at steady state
- WHO
- World Health Organization
- WHO PS
- World Health Organization Performance Status
- yr
- year
About This Database
This database is populated with information on the results of Roche-sponsored clinical trials.